多倍体
生物
再生(生物学)
经济短缺
癌症
癌症研究
癌细胞
倍性
遗传学
基因
语言学
哲学
政府(语言学)
作者
Shiva Moein,Rezvan Adibi,Lindolfo da Silva Meirelles,Nance Beyer Nardi,Yousof Gheisari
标识
DOI:10.1016/j.bbcan.2020.188408
摘要
In spite of significant advancements of therapies for initial eradication of cancers, tumor relapse remains a major challenge. It is for a long time known that polyploid malignant cells are a main source of resistance against chemotherapy and irradiation. However, therapeutic approaches targeting these cells have not been appropriately pursued which could partly be due to the shortage of knowledge on the molecular biology of cell polyploidy. On the other hand, there is a rising trend to appreciate polyploid/ multinucleated cells as key players in tissue regeneration. In this review, we suggest an analogy between the functions of polyploid cells in normal and malignant tissues and discuss the idea that cell polyploidy is an evolutionary conserved source of tissue regeneration also exploited by cancers as a survival factor. In addition, polyploid cells are highlighted as a promising therapeutic target to overcome drug resistance and relapse.
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