细胞凋亡
荧光
碳纤维
体外
体内
细胞
分子内力
生物物理学
纳米技术
化学
材料科学
生物
生物化学
立体化学
复合材料
复合数
物理
生物技术
量子力学
作者
Fanyong Yan,Xiaodong Sun,Tengchuang Ma,Yan Zhang,Yingxia Jiang,Ruijie Wang,Cong Ma,Junfu Wei,Li Chen,Yali Cui
标识
DOI:10.1016/j.cej.2020.127801
摘要
Carbon dots (CDs) as a fluorescent nanomaterial plays an important role in bioimaging and light-emitting devices, and its multifunctionalization will be a promising evolution. Here, by a freely rotatable single bond to connect materials with complementary functions together, a dual-function aggregation-induced emission (AIE) CDs (V-CDs) is obtained to visually monitor the dead of cancerous cells and inhibit the production of vascular endothelial growth factor (VEGF). The fluorescence of V-CDs will change between blue and green as the changes of environment viscosity based on the restriction of intramolecular rotation (RIR) effect. For another, the VEGF content decreased by about 3 times compared with the blank group after V-CDs was introduced. The co-administration group shows the best anti-cancer effect among the rest of control groups after Taxol was involved, and the same result are achieved in vitro and vivo. The performances of V-CDs make it possible to realize the potential of visualizing anti-cancer process.
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