Aerobic Exercise Effects on Cognition: A Functional Near Infrared Spectroscopy Systematic Review

Event Abstract Back to Event Aerobic Exercise Effects on Cognition: A Functional Near Infrared Spectroscopy Systematic Review Melanie N. French1, Felipe Fregni2 and Eunice Y. Chen1* 1 Temple University, Psychoogy, United States 2 Spaulding Rehabilitation Hospital, Department of Physical Medicine and Rehabilitation, United States Introduction: Past studies demonstrate that exercise can improve cognitive and neural functioning. Functional Near-Infrared Spectroscopy (fNIRS) is a cost-effective, novel tool to examine brain activity with several advantages, including superior temporal resolution to functional magnetic resonance imaging (fMRI), superior spatial resolution to electroencephalography (EEG), and is capable of handling motion artifacts allowing for ambulatory applications. Design: The present study is a systematic review designed to describe the effects of aerobic activity on cognitive performance. A PubMed search was conducted using the terms "Functional Near-Infrared Spectroscopy" AND "Physical Activity." All search results were then manually screened. Studies must have included an aerobic intervention or physical fitness level assessment as well as a cognitive task correlated with fNIRS activity. Results: Included Studies: 107 studies were screened, and nine were included in the systematic review. Reasons of exclusion are documented in flowchart (Figure1) using the PRISMA guides (Moher et al., 2009). A summary of study characteristics can be seen in Table 1. Six studies (3 young adult samples and 3 older adult samples) included an acute aerobic exercise session using an ergometer (Byun et al., 2014; Decroix et al., 2016; Hyodo et al., 2012, 2016; Tsujii, Komatsu, & Sakatani, 2013; Yamazaki et al., 2017). One study used actigraphy to compare more and less active children (Mücke, Andrä, Gerber, Pühse, & Ludyga, 2017) . Another looked at a weight-loss intervention program (that included aerobic exercise) for overweight and obese adolescents and young adults (Xu et al., 2017). Finally, a randomized controlled trial investigated the effects of an 8-week aerobic "dance" video game training intervention compared to a control "balance" intervention group, involving stretching and balance training (Eggenberger, Wolf, Schumann, & de Bruin, 2016). Findings Summarized: Inhibitory Control: Six studies (1 adolescent and young adult, 2 adult, and 3 older adult samples) measured performance on the Stroop task, an executive function task of inhibition. Exercise appears to increase left prefrontal oxygenated hemoglobin (oxy-HB) levels in healthy younger adults (Byun et al., 2014; Decroix et al., 2016) and older adults with higher physical activity levels (Hyodo et al., 2016). However, in general older adult populations, contralateral brain activity (on the right side) may serve to compensate for deterioration in left brain regions, such as the left dorsolateral prefrontal cortex (DLPFC) (Hyodo et al., 2012). In an adolescent and young adult sample, increased oxy-HB in brain regions within the left hemisphere (as well as bilateral DLPC) during the Stroop task was positively correlated with weight loss (Xu et al., 2017). Exercise also improved reaction times during Stroop interference conditions for all studies that measured differences pre- and post-exercise (Byun et al., 2014; Decroix et al., 2016). Working Memory: Two studies examined working memory as an outcome. A study in older adults (Tsujii et al., 2013) found an increase in reaction time in a working memory task and increased oxy-HB levels in the left prefrontal cortex during an exercise condition compared with the control condition. A study in younger adults (Yamazaki et al., 2017) found that exercise improved spatial working memory on easier but not more difficult trials. There was no difference in brain activity during the cognitive trials; however, during exercise, those who did improve on the easier spatial working memory trials (responders) had greater activation in the right ventrolateral prefrontal cortex compared to those who did not improve (non-responders). Given the differences in analysis, fNIRS parameters, study population, and intensity levels of these two studies, no global generalizations can be concluded. Neither of these studies reported effect sizes. Other cognitive outcomes: One study comparing physically active children and non-physically active children found no differences in performance during a semantic verbal fluency test (VFT), a phonetic VFT, and a mental arithmetic task. In addition, there were no corresponding brain activation (oxy-HB levels) differences between physically active and non-physically active children (P ≥ 0.268, η2 ≤ 0.02). Conclusion: fNIRS technology shows that acute exercise can influence cognitive performance and is related to increases in prefrontal activation. Specifically, inhibitory tasks (i.e., the Stroop task) appear to be related to increases in left prefrontal activity for younger and more active older adults but right-compensatory activation in older adults. Effects sizes of exercise on cognitive task performance were not reported for any of the studies, however, one reported an effect size (ES) of .66 when looking at brain activity increases after exercise compared to baseline, when averaged across subjects that took a supplement and those who took a placebo (Decroix et al., 2016). Another study found a significant positive correlation (r=.43) between improved Stroop performance and elevated right prefrontal activity in older adults (Eggenberger et al., 2016), whereas a mediation analysis showed, left-lateralized DLPFC mediated the relationship between physical fitness level and Stroop interference time in an older adult sample (R2= 0.289, p < 0.001) (Hyodo et al., 2016). More studies using similar protocols that report effect sizes are needed to quantify the strength of the relationship between exercise and cognition as well as to confirm the current findings. Figure 1 Acknowledgements We would like to thank Jean Arlt and Susan Murray from the Temple Eating Disorder program for helping edit and proof-read the abstract. References Byun, K., Hyodo, K., Suwabe, K., Ochi, G., Sakairi, Y., Kato, M., … Soya, H. (2014). Positive effect of acute mild exercise on executive function via arousal-related prefrontal activations: An fNIRS study. NeuroImage, 98, 336–345. https://doi.org/10.1016/j.neuroimage.2014.04.067 Decroix, L., Tonoli, C., Soares, D. D., Tagougui, S., Heyman, E., & Meeusen, R. (2016). Acute cocoa flavanol improves cerebral oxygenation without enhancing executive function at rest or after exercise. Applied Physiology, Nutrition, and Metabolism, 41(12), 1225–1232. https://doi.org/10.1139/apnm-2016-0245 Eggenberger, P., Wolf, M., Schumann, M., & de Bruin, E. D. (2016). Exergame and balance training modulate prefrontal brain activity during walking and enhance executive function in older adults. Frontiers in Aging Neuroscience, 8(APR). https://doi.org/10.3389/fnagi.2016.00066 Hyodo, K., Dan, I., Kyutoku, Y., Suwabe, K., Byun, K., Ochi, G., … Soya, H. (2016). The association between aerobic fitness and cognitive function in older men mediated by frontal lateralization. NeuroImage, 125, 291–300. https://doi.org/10.1016/j.neuroimage.2015.09.062 Hyodo, K., Dan, I., Suwabe, K., Kyutoku, Y., Yamada, Y., Akahori, M., … Soya, H. (2012). Acute moderate exercise enhances compensatory brain activation in older adults. Neurobiology of Aging, 33(11), 2621–2632. https://doi.org/10.1016/j.neurobiolaging.2011.12.022 Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., Altman, D., Antes, G., … Tugwell, P. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1000097 Mücke, M., Andrä, C., Gerber, M., Pühse, U., & Ludyga, S. (2017). Moderate-to-vigorous physical activity, executive functions and prefrontal brain oxygenation in children: A functional near-infrared spectroscopy study. Journal of Sports Sciences, 1–7. https://doi.org/10.1080/02640414.2017.1326619 Tsujii, T., Komatsu, K., & Sakatani, K. (2013). Acute effects of physical exercise on prefrontal cortex activity in older adults: A functional near-infrared spectroscopy study. In Advances in Experimental Medicine and Biology (Vol. 765, pp. 293–298). https://doi.org/10.1007/978-1-4614-4989-8-41 Xu, X., Deng, Z.-Y., Huang, Q., Zhang, W.-X., Qi, C., & Huang, J.-A. (2017). Prefrontal cortex-mediated executive function as assessed by Stroop task performance associates with weight loss among overweight and obese adolescents and young adults. Behavioural Brain Research, 321, 240–248. https://doi.org/10.1016/j.bbr.2016.12.040 Yamazaki, Y., Sato, D., Yamashiro, K., Tsubaki, A., Yamaguchi, Y., Takehara, N., & Maruyama, A. (2017). Inter-individual differences in exercise-induced spatial working memory improvement: A near-infrared spectroscopy study. Advances in Experimental Medicine and Biology, 977, 81–88. https://doi.org/10.1007/978-3-319-55231-6_12 Keywords: Exercise, physical activity, fNIRS, functional near-infrared spectroscopy, executive functioning, Systematic review Conference: 2nd International Neuroergonomics Conference, Philadelphia, PA, United States, 27 Jun - 29 Jun, 2018. Presentation Type: Poster Presentation Topic: Neuroergonomics Citation: French MN, Fregni F and Chen EY (2019). Aerobic Exercise Effects on Cognition: A Functional Near Infrared Spectroscopy Systematic Review. Conference Abstract: 2nd International Neuroergonomics Conference. doi: 10.3389/conf.fnhum.2018.227.00064 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers' terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 Apr 2018; Published Online: 27 Sep 2019. * Correspondence: Dr. Eunice Y Chen, Temple University, Psychoogy, Philadelphia, PA, 19122, United States, Eunice.Chen@temple.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. 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