炎症
模式识别受体
促炎细胞因子
先天免疫系统
潮湿
趋化因子
免疫学
发病机制
细胞外
医学
中性粒细胞胞外陷阱
受体
免疫系统
细胞内
生物
细胞生物学
内科学
物理
气象学
作者
Xu Wang,Victor Antony,Yixin Wang,Gaojun Wu,Guang Liang
摘要
Abstract The innate immune system contains multiple classes of pattern recognition receptors (PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) in the intracellular and extracellular space. Although PRRs are indispensable for the detection and clearance of invading pathogens, dysregulated PRR activation by extrinsic and intrinsic factors leads to inflammatory diseases. PRR‐mediated inflammation has been shown to play a pivotal role in the pathogenesis of diabetic vascular complications (DVCs), which are the leading causes of morbidity and mortality in diabetic patients. Upon sensing hyperglycemia‐generated DAMPs, PRRs activate intracellular signaling pathways leading to the production of proinflammatory cytokines and chemokines in various cells of the kidney, brain, eye, and heart. The resulting chronic, low‐grade inflammation contributes to DVCs. In this review, we summarize the role of PRRs in DVCs including diabetic nephropathy, neuropathy, retinopathy, and cardiomyopathy. We propose that targeting PRRs and associated signaling pathways may be beneficial for the management of DVCs.
科研通智能强力驱动
Strongly Powered by AbleSci AI