Trichoderma-functional metabolomics to genetic engineering

Abstract Filamentous fungi are a major source of industrial biotechnology due to their applicability in productions of primary and secondary metabolites, enzymes, and recombinant proteins. Trichoderma strains are widely used in various agricultural and industrial applications. Recent development in molecular tools is capable of modifying the genetic material of the fungus to increase the primary production of metabolites. Therefore, understanding of the genetic pathways involved in the metabolites synthesis significantly related to the expression of the genome clusters in Trichoderma. The regulation of genome through using the current molecular techniques can trigger higher production of targeted metabolites. Hence, this book chapter reviews the genomic regulation for functional genes of metabolites and enzymes in Trichoderma.