Medication-Related Osteonecrosis of the Jaw—Comparison of Bone Imaging Using Ultrashort Echo-Time Magnetic Resonance Imaging and Cone-Beam Computed Tomography

医学 锥束ct 磁共振成像 颌骨骨坏死 核医学 放射科 双膦酸盐相关性颌骨骨坏死 计算机断层摄影术 骨质疏松症 双膦酸盐 病理
作者
Florian A. Huber,Paul Schumann,Jochen von Spiczak,Moritz C. Wurnig,Markus Klarhöfer,Tim Finkenstaedt,Alberto Bedogni,Roman Guggenberger
出处
期刊:Investigative Radiology [Lippincott Williams & Wilkins]
卷期号:55 (3): 160-167 被引量:22
标识
DOI:10.1097/rli.0000000000000617
摘要

Objective The aim of this study was to compare bone imaging between ultrashort echo-time (UTE) magnetic resonance (MR) imaging and cone-beam computed tomography (CBCT) as the reference standard in patients with medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods A 1-year retrospective, blinded, and randomized qualitative analysis of UTE MR images and CBCT from 19 patients with clinically diagnosed MRONJ was performed by 2 independent radiologists. Medication-related osteonecrosis of the jaw imaging hallmarks such as osteolysis, periosteal thickening, and medullary osteosclerosis were rated visually (0 and 1 to 3 for normal and mild to severe changes) for defined anatomic regions of the jaw. In addition, segmentation of these regions was performed on coregistered MR/CBCT images for the following quantitative comparison of signal intensity (SI) on MR and gray values (GVs) on CBCT images. Interreader/modality agreement (Cohen kappa), standard testing for significant differences of (non)parametric values, and Pearson correlation of signal intensity/GV were used for statistical analysis. Results The anterior corpus of the mandible was most often affected by MRONJ ( P < 0.001). Overall, interreader agreement of qualitative MRONJ hallmark scores was almost perfect (κ = 0.81) and without significant differences between modalities (κ = 0.81 vs 0.82, CBCT vs MR, respectively). Intermodality agreement for qualitative gradings was substantial for both readers (κ = 0.77 and 0.70). Signal intensity/GV in MRONJ-affected areas differed significantly from healthy bone ( P < 0.001) as well as correlation significantly between modalities ( r = −0.77; P < 0.001). Conclusions Qualitative assessment of MRONJ with radiation-free UTE MR imaging is comparable to reference standard CBCT. Quantitative measurements of both modalities significantly distinguish diseased from normal bone with strong correlations among the quantitative values in both modalities.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
桐桐应助完美梨愁采纳,获得10
1秒前
Mm林完成签到,获得积分10
2秒前
我就是我完成签到,获得积分10
2秒前
盈滢完成签到 ,获得积分10
2秒前
Jay_Gavin应助白白采纳,获得10
3秒前
zy发布了新的文献求助10
4秒前
Liang发布了新的文献求助10
4秒前
美丽的楼房完成签到 ,获得积分10
6秒前
6秒前
大观天下完成签到,获得积分10
7秒前
端庄的冬天完成签到,获得积分10
7秒前
所所应助yizhe采纳,获得10
7秒前
高大的静曼完成签到,获得积分10
8秒前
JK完成签到,获得积分10
9秒前
景行行止完成签到,获得积分10
9秒前
草原狼完成签到,获得积分10
9秒前
9秒前
gexiaoyang完成签到 ,获得积分10
10秒前
量子星尘发布了新的文献求助10
11秒前
小二郎应助自信的孱采纳,获得10
11秒前
小马甲应助小王采纳,获得10
12秒前
伶俐的秋白完成签到,获得积分10
12秒前
12秒前
思源应助维生素采纳,获得10
13秒前
13秒前
完美梨愁发布了新的文献求助10
16秒前
16秒前
17秒前
英俊的铭应助白兰鸽采纳,获得10
19秒前
布洛小芬完成签到 ,获得积分20
20秒前
whatever应助shark采纳,获得20
20秒前
默默雪旋完成签到 ,获得积分10
20秒前
牧紫菱完成签到,获得积分10
21秒前
22秒前
23秒前
小王发布了新的文献求助10
23秒前
23秒前
Eric完成签到,获得积分10
24秒前
开朗的山彤完成签到,获得积分10
24秒前
维生素完成签到,获得积分10
24秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029