Genetics of Fuchs Endothelial Corneal Dystrophy

Fuchs endothelial corneal dystrophy (FECD) is one of the most common indicators for corneal transplantation caused by accidents. Previously, FECD was not common in our country, but now an increasing number of FECD patients are diagnosed in concurrence with the development of ophthalmology. As a result, the pathogenesis of FECD has gradually gained more attention. The pathogenesis of FECD is highly complex; it is the result of the interaction between genetic and environmental factors. In this paper, we focus on the genetic basis of FECD. Studying the genetic basis can foster a better understanding of the pathogenesis of FECD and lay a foundation for finding a non-surgical treatment for it. Key words: Fuchs endothelial corneal dystrophy; pathogenesis; genetics