Monitoring perfusion and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy

医学 光动力疗法 病理 灌注 波尔图葡萄酒 核医学 心脏病学 外科 化学 有机化学
作者
Defu Chen,Ying Wang,He Zhao,Haixia Qiu,Yongtian Wang,Jian Feng Yang,Ying Gu
出处
期刊:Annals of Translational Medicine [AME Publishing Company]
卷期号:9 (3): 214-214 被引量:6
标识
DOI:10.21037/atm-20-3210
摘要

Background: Vascular targeted photodynamic therapy (V-PDT) is a safe and effective therapeutic modality for port-wine stains (PWS) by targetedly damaging the dilated and malformed blood vessels.This study aims to monitor and quantify the changes in oxygen saturation (StO 2 ), blood volume fraction (BVF) and perfusion in PWS lesions before and during V-PDT.Methods: Microvascular parameters (i.e., StO 2 and BVF) and skin perfusion were measured noninvasively by using diffuse reflectance spectroscopy (DRS) and laser Doppler imaging (LDI), respectively.The change in StO 2 , BVF and perfusion that occurred in the PWS lesions of 26 patients were monitored and investigated before and during V-PDT in vivo with the systematic administration of the porphyrin-based photosensitizer HiPorfin.Results: The mean StO 2 (P<0.05),BVF (P<0.05), and perfusion (P<0.001) in PWS lesions of all subjects significantly increased by 6%, 34%, and 113%, respectively, 3 min after the initiation of V-PDT.The StO 2 increased first and fluctuated during V-PDT.The overall trend of BVF change was consistent with the perfusion change.The BVF and the perfusion of PWS lesions increased after the initiation of V-PDT, and then gradually decreased.Conclusions: V-PDT is an effective therapeutic modality in treating PWS.Results showed that LDI and DRS permitted the noninvasive monitoring of the changes in StO 2 , BVF, and perfusion in PWS lesions during V-PDT, and these methods can be useful in facilitating our understanding of the basic physiological mechanisms during V-PDT.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
汉堡包应助blue采纳,获得10
2秒前
王小茗发布了新的文献求助10
2秒前
谦让鹏涛发布了新的文献求助10
3秒前
lry关闭了lry文献求助
3秒前
3秒前
3秒前
4秒前
陈泽宇发布了新的文献求助10
5秒前
Aaernan完成签到 ,获得积分10
5秒前
超级冷松完成签到 ,获得积分10
5秒前
zzzb完成签到,获得积分10
5秒前
greenmsp发布了新的文献求助10
6秒前
在水一方应助zzzzzzzzzl采纳,获得10
6秒前
袁硕完成签到 ,获得积分10
6秒前
tz完成签到,获得积分10
7秒前
7秒前
Lucas应助123采纳,获得10
7秒前
7秒前
CodeCraft应助Z1采纳,获得30
9秒前
双珠发布了新的文献求助10
9秒前
爆米花应助zzzb采纳,获得10
9秒前
9秒前
思源应助张总可以的采纳,获得10
9秒前
小张123发布了新的文献求助10
9秒前
augenstern完成签到,获得积分10
10秒前
王小茗完成签到,获得积分10
10秒前
10秒前
李哈哈发布了新的文献求助10
10秒前
10秒前
谦让鹏涛完成签到,获得积分10
11秒前
dingbeicn完成签到,获得积分10
11秒前
喜欢小葵花生油完成签到,获得积分10
11秒前
桐桐应助纯牛奶采纳,获得10
12秒前
双离子完成签到,获得积分10
12秒前
zw发布了新的文献求助10
12秒前
默默荔枝完成签到 ,获得积分10
13秒前
仇道罡发布了新的文献求助10
13秒前
FOLY发布了新的文献求助30
13秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3245628
求助须知:如何正确求助?哪些是违规求助? 2889319
关于积分的说明 8257790
捐赠科研通 2557674
什么是DOI,文献DOI怎么找? 1386378
科研通“疑难数据库(出版商)”最低求助积分说明 650327
邀请新用户注册赠送积分活动 626633