神经刺激
收发机
无线
神经假体
传感器
计算机科学
生物医学工程
电气工程
刺激
医学
工程类
电信
内科学
作者
David K. Piech,Benjamin C. Johnson,Konlin Shen,Mohammad Meraj Ghanbari,Ka Yiu Li,Ryan Neely,Joshua E. Kay,Jose M. Carmena,Michel M. Maharbiz,Rikky Muller
标识
DOI:10.1038/s41551-020-0518-9
摘要
Clinically approved neural stimulators are limited by battery requirements, as well as by their large size compared with the stimulation targets. Here, we describe a wireless, leadless and battery-free implantable neural stimulator that is 1.7 mm3 and that incorporates a piezoceramic transducer, an energy-storage capacitor and an integrated circuit. An ultrasonic link and a hand-held external transceiver provide the stimulator with power and bidirectional communication. The stimulation protocols were wirelessly encoded on the fly, reducing power consumption and on-chip memory, and enabling protocol complexity with a high temporal resolution and low-latency feedback. Uplink data indicating whether stimulation occurs are encoded by the stimulator through backscatter modulation and are demodulated at the external transceiver. When embedded in ex vivo porcine tissue, the integrated circuit efficiently harvested ultrasonic power, decoded downlink data for the stimulation parameters and generated current-controlled stimulation pulses. When cuff-mounted and acutely implanted onto the sciatic nerve of anaesthetized rats, the device conferred repeatable stimulation across a range of physiological responses. The miniaturized neural stimulator may facilitate closed-loop neurostimulation for therapeutic interventions. A wireless and battery-free 1.7-mm3 neural stimulator implanted onto the sciatic nerve of rats allows for repeatable stimulation across a range of physiological responses.
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