吲哚胺2,3-双加氧酶
化学
透视图(图形)
癌症
机制(生物学)
癌症治疗
功能(生物学)
计算生物学
药理学
生物化学
色氨酸
内科学
认识论
医学
进化生物学
生物
哲学
人工智能
氨基酸
计算机科学
作者
Xi Feng,Liao Dong-dong,Dongyu Liu,Ping An,Zhiyu Li,Jinlei Bian
标识
DOI:10.1021/acs.jmedchem.0c00925
摘要
Indoleamine 2,3-dioxygenase 1 (IDO1) has received increasing attention due to its immunosuppressive function in connection with various diseases, including cancer. A recent increase in the understanding of IDO1 has significantly contributed to the discovery of numerous novel inhibitors, but the latest clinical outcomes raised questions and have indicated a future direction of IDO1 inhibition for therapeutic approaches. Herein, we present a comprehensive review of IDO1, discussing the latest advances in understanding the IDO1 structure and mechanism, an overview of recent IDO1 inhibitor discoveries and potential therapeutic applications to provide helpful information for medicinal chemists investigating IDO1 inhibitors.
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