炎症体
上睑下垂
促炎细胞因子
点头
化学
细胞生物学
受体
炎症
小分子
神经炎症
吡喃结构域
模式识别受体
信号转导
半胱氨酸蛋白酶1
先天免疫系统
免疫学
生物
生物化学
基因
作者
Xiangna Zhang,Ana Xu,Jiahui Lv,Qiuqiong Zhang,Yingying Ran,Chao Wei,Jingde Wu
标识
DOI:10.1016/j.ejmech.2019.111822
摘要
NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is activated by pathogen and damage-associated signals to form a multimeric protein complex, known as the NLRP3 inflammasome. NLRP3 inflammasome activation leads to release of proinflammatory cytokines IL-1β and IL-18, thus inducing pyroptosis, a programmed cell death mechanism. Dysregulation of the NLRP3 inflammasome pathway is closely related to the development of many human diseases, such as neuroinflammation, metabolic inflammation, and immune inflammation. Emerging studies have suggested NLRP3 inflammasome as a potential drug-target for inflammatory diseases. Several small molecules have recently been identified to target the NLRP3 inflammasome pathway directly or indirectly and alleviate related disease pathology. This review summarizes recent evolving landscape of small molecule inhibitor development targeting the NLRP3 inflammasome pathway.
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