明胶
自愈水凝胶
伤口愈合
材料科学
硼砂
生物医学工程
伤口敷料
原位
防腐剂
化学
复合材料
外科
高分子化学
医学
有机化学
原材料
生物化学
作者
Biji Balakrishnan,Malaya Mohanty,P. R. Umashankar,A. Jayakrishnan
出处
期刊:Biomaterials
[Elsevier]
日期:2005-05-25
卷期号:26 (32): 6335-6342
被引量:892
标识
DOI:10.1016/j.biomaterials.2005.04.012
摘要
Wound dressings that can be formed in situ offer several advantages over the use of preformed dressings such as conformability without wrinkling or fluting in the wound bed, ease of application and improved patient compliance and comfort. Here we describe such an in situ forming hydrogel wound dressing from gelatin, oxidized alginate and borax. Periodate oxidized alginate rapidly cross-links proteins such as gelatin in the presence of borax to give in situ forming hydrogels that are both non-toxic and biodegradable. The composite matrix has the haemostatic effect of gelatin, the wound healing-promoting feature of alginate and the antiseptic property of borax to make it a potential wound dressing material. The hydrogel was found to have a fluid uptake of 90% of its weight which would prevent the wound bed from accumulation of exudates. The water vapour transmission rate (WVTR) of the hydrogel was found to be 2686±124 g/m2/day indicating that the hydrogel can maintain a moist environment over wound bed in moderate to heavily exuding wound which would enhance epithelial cell migration during the healing process. The wound healing efficacy of hydrogel was evaluated in experimental full thickness wounds using a rat model which demonstrated that within 2 weeks, the wound covered with gel was completely filled with new epithelium without any significant adverse reactions. These in situ forming hydrogels fulfil many critical elements desirable in a wound dressing material.
科研通智能强力驱动
Strongly Powered by AbleSci AI