斯达
JAK-STAT信号通路
生物
贾纳斯激酶
信号转导
细胞生物学
转录因子
状态4
模式生物
计算生物学
遗传学
基因
车站3
受体酪氨酸激酶
作者
Qian Chen,Michelle S. Giedt,Lingfeng Tang,Douglas A. Harrison
出处
期刊:Methods
[Elsevier]
日期:2014-06-01
卷期号:68 (1): 160-172
被引量:23
标识
DOI:10.1016/j.ymeth.2014.03.023
摘要
The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway is one of a limited number of signaling cascades that is extensively utilized for many developmental and homeostatic functions. The JAK/STAT pathway is evolutionarily conserved from insects to mammals, with homologous transduction machinery in each. Yet the mammalian pathway is composed of multiple members for each family of proteins, while flies have only a single homologue of most pathway components. This simplicity and the abundance of genetic, biochemical, and developmental tools make Drosophila an attractive model to investigate this important signaling pathway. This review provides a basic description of the Drosophila JAK/STAT cascade and summarizes currently available reagents and tools to study and manipulate the pathway.
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