光热治疗
吲哚青绿
体内
材料科学
叶酸受体
体内分布
荧光寿命成像显微镜
纳米颗粒
荧光
生物物理学
生物医学工程
纳米技术
癌症研究
癌细胞
癌症
医学
病理
光学
生物
生物技术
内科学
物理
作者
Caixia Yue,Peng Liu,Mingbin Zheng,Pengfei Zhao,Yiqing Wang,Yifan Ma,Lintao Cai
出处
期刊:Biomaterials
[Elsevier]
日期:2013-09-01
卷期号:34 (28): 6853-6861
被引量:329
标识
DOI:10.1016/j.biomaterials.2013.05.071
摘要
IR-780 iodide is a near-infrared (NIR) fluorescence dye with higher and more stable fluorescence intensity than clinically applied dye indocyanine green (ICG). Meanwhile, IR-780 can be utilized in photothermal therapy with laser irradiation. IR-780 is an important theranostic agent but its lipophilicity limited its application. In this paper, we synthesize multifunctional heparin-folic acid-IR-780 nanoparticles (HF-IR-780 NPs) by self-assembly of the heparin-folic acid conjugate and IR-780 through ultrasonic sound method. The HF-IR-780 NPs exhibit good monodispersity, significant stability, and excellent molecular targeting to folate receptor over-expressing MCF-7 cells. Furthermore, the in vivo biodistribution experiments show that the HF-IR-780 NPs are specifically targeted to the tumor and can be used for tumor imaging. The in vitro cell viability assays and in vivo photothermal therapy experiments indicate that MCF-7 cells or MCF-7 xenograft tumors could be ablated by combining HF-IR-780 NPs with irradiation of an 808 nm laser. The photothermal therapy in vivo with a single-dose treatment has not caused significant adverse effect. The resulted HF-IR-780 NPs are a potential theranostic agent for imaging-guided cancer therapy.
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