亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Short- and Long-Term Outcomes With Drug-Eluting and Bare-Metal Coronary Stents

医学 支架 内科学 心肌梗塞 佐他莫司 心脏病学 靶病变 经皮冠状动脉介入治疗 药物洗脱支架 依维莫司 血运重建 外科
作者
Sripal Bangalore,Sunil Kumar,Maria Fusaro,Nicholas Amoroso,Michael Attubato,Frederick Feit,Deepak L. Bhatt,James Slater
出处
期刊:Circulation [Lippincott Williams & Wilkins]
卷期号:125 (23): 2873-2891 被引量:542
标识
DOI:10.1161/circulationaha.112.097014
摘要

Background— Drug-eluting stents (DES) have been in clinical use for nearly a decade; however, the relative short- and long-term efficacy and safety of DES compared with bare-metal stents (BMS) and among the DES types are less well defined. Methods and Results— PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for randomized clinical trials, until March 2012, that compared any of the Food and Drug Administration–approved durable stent and polymer DES (sirolimus-eluting stent [SES], paclitaxel-eluting stent [PES], everolimus-eluting stent [EES], zotarolimus-eluting stent [ZES], and ZES-Resolute [ZES-R]) with each other or against BMS for de novo coronary lesions, enrolling at least 100 patients and with follow-up of at least 6 months. Short-term (≤1 year) and long-term efficacy (target-vessel revascularization, target-lesion revascularization) and safety (death, myocardial infarction, stent thrombosis) outcomes were evaluated and trial-level data pooled by both mixed-treatment comparison and direct comparison analyses. From 76 randomized clinical trials with 117 762 patient-years of follow-up, compared with BMS, each DES reduced long-term target-vessel revascularization (39%–61%), but the magnitude varied by DES type (EES∼SES∼ZES-R>PES∼ZES>BMS), with a >42% probability that EES had the lowest target-vessel revascularization rate. There was no increase in the risk of any long-term safety outcomes, including stent thrombosis, with any DES (versus BMS). In addition, there was reduction in myocardial infarction (all DES except PES versus BMS) and stent thrombosis (with EES versus BMS: Rate ratio, 0.51; 95% credibility interval, 0.35–0.73). The safest DES appeared to be EES (>86% probability), with reduction in myocardial infarction and stent thrombosis compared with BMS. Short-term outcomes were similar to long-term outcomes, with SES, ZES-R, and everolimus-eluting stent being the most efficacious and EES being the safest stent. Conclusions— DES are highly efficacious at reducing the risk of target-vessel revascularization without an increase in any safety outcomes, including stent thrombosis. However, among the DES types, there were considerable differences, such that EES, SES, and ZES-R were the most efficacious and EES was the safest stent.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
怕孤单的思雁完成签到,获得积分10
18秒前
闫雪发布了新的文献求助10
26秒前
gszy1975完成签到,获得积分10
39秒前
TiYooY完成签到,获得积分10
47秒前
Benhnhk21发布了新的文献求助10
56秒前
1分钟前
科研通AI2S应助科研通管家采纳,获得50
1分钟前
5433完成签到 ,获得积分10
2分钟前
jiangjiang完成签到 ,获得积分10
2分钟前
吱吱草莓派完成签到 ,获得积分10
2分钟前
3分钟前
小二郎应助科研通管家采纳,获得10
3分钟前
3分钟前
3分钟前
宝贝丫头完成签到 ,获得积分10
3分钟前
英姑应助背后的鞋垫采纳,获得10
3分钟前
桐桐应助Benhnhk21采纳,获得10
3分钟前
Dave发布了新的文献求助10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
5分钟前
Aaron完成签到 ,获得积分0
5分钟前
5分钟前
8分钟前
Liufgui应助Dave采纳,获得10
8分钟前
Benhnhk21发布了新的文献求助10
8分钟前
yydragen应助yyds采纳,获得10
8分钟前
Hisam完成签到,获得积分10
8分钟前
lhy完成签到,获得积分10
8分钟前
lhy发布了新的文献求助10
8分钟前
8分钟前
积极的台灯应助Benhnhk21采纳,获得10
8分钟前
Hisam发布了新的文献求助10
8分钟前
yyds完成签到,获得积分0
8分钟前
科研通AI2S应助科研通管家采纳,获得10
9分钟前
木木完成签到 ,获得积分10
9分钟前
9分钟前
董可以发布了新的文献求助10
9分钟前
小马甲应助董可以采纳,获得10
9分钟前
10分钟前
Boren发布了新的文献求助10
10分钟前
梨子完成签到,获得积分10
10分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990298
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256481
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805197
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234