偶氮甲烷
炎症性肠病
结肠炎
溃疡性结肠炎
医学
结直肠癌
发育不良
癌症
致癌物
炎症
免疫系统
疾病
肠上皮
癌症研究
免疫学
胃肠病学
内科学
上皮
病理
生物
遗传学
作者
Ashley J. Snider,Agnieszka B. Bialkowska,Amr M. Ghaleb,Vincent W. Yang,Lina M. Obeid,Yusuf A. Hannun
出处
期刊:Methods in molecular biology
日期:2016-01-01
卷期号:: 245-254
被引量:83
标识
DOI:10.1007/978-1-4939-3661-8_14
摘要
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.
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