Sa2019 GLP-1R Expression Increases in the Enteric Nerve System of Parkinson's Disease Rat Model With Gastrointestinal Dysfunction

assessed 24-hr and 2 week post last bTBI using gait-dynamics, startle and pre-pulse inhibition responses and learning in the water maze.RESULTS: A difference in the microbial alpha diversity was observed between bTBIs (S-BTI and R-TBI) and the sham group.Compared to sham, MLNs from bTBIs had increased Actinomycetales Coriobacteriaceae (sham:4.6%vs bTBI:11.6%)and lower Firmicutes (sham:23% vs bTBI:14%) of the total bacterial load.MLNs collected at 2 weeks in the R-BTI group had higher loads of both the Actinomycetales Coriobacteriaceae and Firmicutes than those of S-TBI.Colonic motility was reduced post S-TBI and increased post R-TBI.Both S-TBI and R-TBI, compared to sham rats, showed persistent alterations in gait-dynamics, startle and pre-pulse inhibition responses and learning in the water maze that developed fully after the repeated blast.CONCLUSION: bTBI modulates microbial load to intestinal MLNs, alters colonic motility as well as motor, behavior and cognition in rats.Gut function is altered in bTBI and changes in gut function in bTBI may serve to assess the severity of injury following acute or chronic bTBI.Supported by R01DK078676 (MM);VA-RR&D #B5089R (OS).