Immunologic Effects of Low Levels of Ochratoxin A in Ovo: Utilization of a Chicken Embryo Model

在ovo 生物 胚胎 赭曲霉毒素A 孵化 法氏囊 脾脏 抗体 男科 接种 赭曲霉毒素 抗原 微生物学 免疫学 真菌毒素 食品科学 医学 生物化学 细胞生物学
作者
Roger B. Harvey,L.F. Kubena,S. A. Naqi,J E Gyimah,Donald E. Corrier,B. Panigrahy,Timothy D. Phillips
出处
期刊:Avian Diseases [American Association of Avian Pathologists]
卷期号:31 (4): 787-787 被引量:14
标识
DOI:10.2307/1591032
摘要

Ochratoxin A (OA) was administered to 13-day-old chicken embryos via the chorioallantoic membrane. The 7-day LD50 value (day 20 incubation) of OA was calculated at 7.9 micrograms of OA. Ochratoxin-treated embryos (2.5 micrograms) had slight but significant changes in numbers of immunoglobulin-bearing cells in the bursa but not in the spleen. Chicks hatched from in ovo-treated eggs were challenged with 9 X 10(4) colony-forming units (CFU) of beta-hemolytic Escherichia coli (O1:K1) at 7 days of age via the thoracic air sac. Lesion scores of OA-treated chicks were equal to or less severe than those of controls. Hatchmates of the above chicks were vaccinated with a homologous killed E. coli bacterin (O1:K1) at both 2 and 4 weeks of age and challenged with 10(4) CFU of E. coli at 7 weeks. Post-challenge lesions were present in three vaccinated untreated controls and no OA-treated chicks. We conclude that although in ovo exposure to OA may marginally suppress immunoglobulin-bearing cells of bursa, chicks hatched from OA-treated eggs respond as well as controls to an antigen and resist infection by a virulent organism.

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