镉
砷
电感耦合等离子体质谱法
铬
化学
锰
锌
镍
钴
检出限
铜
质谱法
尿
色谱法
钼
感应耦合等离子体
无机化学
有机化学
物理
等离子体
量子力学
生物化学
作者
Maria A. Velez‐Quinones,Hanna Xu,Nhu Vo,Joanna M. Gaitens,Melissa A. McDiarmid,Michael R. Lewin‐Smith,Frederick G. Strathmann
摘要
Abstract We developed and validated a method for the assessment of thirteen separate trace and toxic elements using Inductively Coupled Plasma‐Mass Spectrometry (ICP‐MS). Included elements were as follows: aluminum, chromium, manganese, iron, cobalt, nickel, copper, zinc, arsenic, molybdenum, cadmium, tungsten, and lead. The measurements of all elements in urine samples were conducted using ICAP‐Q ICP‐MS in a single method. The performance characteristics of the assay were determined according to clinical laboratory standards. The assay was linear in the concentration range of 1.0 to 1000.0 µg/liter for all elements. The method was precise and accurate with limits of quantitation of 1 µg/liter for chromium, manganese, cobalt, nickel, copper, cadmium, tungsten, and lead; 2 µg/liter for iron and arsenic; 5 µg/liter for aluminum; and 50 µg/liter for zinc. This method has successfully been used for the assessment of all thirteen elements included in urine and has been shown to be effective as a simple, precise, and sensitive analytical technique for biological monitoring of urine samples. © 2018 by John Wiley & Sons, Inc.
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