癌症研究
CD24型
医学
肿瘤进展
单克隆抗体
基因沉默
免疫疗法
癌症
内科学
免疫学
乳腺癌
生物
抗体
生物化学
基因
作者
Yanghong Ni,Xia Zhao,Wei Wang
标识
DOI:10.2174/1566523220666200623170738
摘要
CD24, is a mucin-like GPI-anchored molecules. By immunohistochemistry, it is widely detected in many solid tumors, such as breast cancers, genital system cancers, digestive system cancers, neural system cancers and so on. The functional roles of CD24 are either fulfilled by combination with ligands or participate in signal transduction, which mediate the initiation and progression of neoplasms. However, the character of CD24 remains to be intriguing because there are still opposite voices about the impact of CD24 on tumors. In preclinical studies, CD24 target therapies, including monoclonal antibodies, target silencing by RNA interference and immunotherapy, have shown us brighten futures on the anti-tumor application. Nevertheless, evidences based on clinical studies are urgently needed. Here, with expectancy to spark new ideas, we summarize the relevant studies about CD24 from a tumor perspective.
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