Ulrich Limper,Jens Tank,Tobias Ahnert,Marc Maegele,Oliver Grottke,Marc Hein,Jens Jordan
出处
期刊:European Heart Journal [Oxford University Press] 日期:2020-05-19卷期号:42 (1): 97-100被引量:22
标识
DOI:10.1093/eurheartj/ehaa359
摘要
Abstract The first ever venous thrombotic condition associated with spaceflight, an internal jugular vein thrombus requiring anticoagulation, has recently been reported. Systematic investigation of space travel-associated thrombotic risk has not been conducted. Cellular, animal, and human studies performed in ground-based models and in actual weightlessness revealed influences of weightlessness and gravity on the blood coagulation system. However, human study populations were small and limited to highly selected participants. Evidence in individuals with medical conditions and older persons is lacking. Evidence for thrombotic risk in spaceflight is unsatisfactory. This issue deserves further study in heterogeneous, high risk populations to find prevention strategies and to enable safe governmental and touristic human spaceflight.