破骨细胞
细胞生物学
兰克尔
表型
巨噬细胞集落刺激因子
骨吸收
神经科学
成骨细胞
吞噬作用
骨免疫学
传出细胞增多
作者
Ji-Won Lee,In-Hee Lee,Tadahiro Iimura,Sek Won Kong
出处
期刊:Bone research
[Springer Nature]
日期:2021-02-10
卷期号:9 (1): 11-11
被引量:6
标识
DOI:10.1038/s41413-020-00134-w
摘要
Tissue-resident macrophages are highly specialized to their tissue-specific microenvironments, activated by various inflammatory signals and modulated by genetic and environmental factors. Osteoclasts and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and Alzheimer's disease (AD), respectively. Osteoporosis is more frequently observed in individuals with AD compared to the prevalence in general population. Diagnosis of AD is often delayed until underlying pathophysiological changes progress and cause irreversible damages in structure and function of brain. As such earlier diagnosis and intervention of individuals at higher risk would be indispensable to modify clinical courses. Pleiotropy is the phenomenon that a genetic variant affects multiple traits and the genetic correlation between two traits could suggest a shared molecular mechanism. In this review, we discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain, respectively, is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD.
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