High-purity weight-bearing magnesium screw: Translational application in the healing of femoral neck fracture

应力屏蔽 股骨颈 股骨头 固定(群体遗传学) 骨愈合 材料科学 负重 内固定 生物医学工程 外科 医学 骨质疏松症 植入 环境卫生 内分泌学 人口
作者
Shibo Huang,Benjie Wang,Xiuzhi Zhang,Fangfang Lu,Zongpu Wang,Simiao Tian,Dongyi Li,Jiahui Yang,Fang Cao,Liang Cheng,Ziqi Gao,Yangde Li,Kai‐Rong Qin,Dewei Zhao
出处
期刊:Biomaterials [Elsevier BV]
卷期号:238: 119829-119829 被引量:66
标识
DOI:10.1016/j.biomaterials.2020.119829
摘要

Magnesium (Mg)-based metals can be used as next-generation fracture internal fixation devices due to their specific properties. We used vascularized bone grafting fixed by degradable pure Mg screws and obtained satisfactory results in the treatment of osteonecrosis of the femoral head. However, the mechanical properties of these screws make them weaker than those made of traditional metals. In particular, one of the main challenges of using screws made of Mg-based metals is their application in fixation at important weight-bearing sites in the human body. Femoral neck fracture is a common clinical injury. In this injury, the large bearing stress at the junction requires a fixation device with extremely high mechanical strength. Surgery and appropriate internal fixation can accelerate the healing of femoral neck fractures. Traditional internal fixation devices have some disadvantages after surgery, including stress shielding effects and the need for secondary surgery to remove screws. On the basis of previous work, we developed high-strength pure Mg screws for femoral neck fractures. In this study, we describe the first use of high-purity Mg to prepare large-size weight-bearing screws for the fixation of femoral neck fractures in goats. We then performed a 48 weeks follow-up study using in vivo transformation experiments. The results show that these biodegradable high-purity Mg weight-bearing screws had sufficient mechanical strength and a degradation rate compatible with bone repair. Furthermore, good bone formation was achieved during the degradation process and reconstruction of the bone tissue and blood supply of the femoral head and femoral neck. This study provides a basis for future research on the clinical transformation of biodegradable high-purity Mg weight-bearing screws.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
魔幻擎宇完成签到,获得积分20
1秒前
1秒前
ddz完成签到,获得积分10
2秒前
滕擎完成签到,获得积分10
2秒前
我是老大应助周周采纳,获得10
2秒前
杨瑞完成签到,获得积分10
2秒前
阿宝发布了新的文献求助10
2秒前
3秒前
咖啡续命完成签到,获得积分10
3秒前
飞哥发布了新的文献求助10
3秒前
飞云发布了新的文献求助30
4秒前
SJAW完成签到,获得积分10
4秒前
英俊的铭应助菲菲采纳,获得10
5秒前
5秒前
汤飞柏发布了新的文献求助20
5秒前
萝卜完成签到,获得积分10
5秒前
6秒前
6秒前
xiaowang发布了新的文献求助10
7秒前
8秒前
10秒前
萝卜发布了新的文献求助10
10秒前
10秒前
时柚发布了新的文献求助10
10秒前
asule13发布了新的文献求助10
10秒前
3242晶完成签到,获得积分10
11秒前
11秒前
11秒前
11秒前
深情的幼南完成签到,获得积分10
11秒前
12秒前
12秒前
周周完成签到,获得积分10
12秒前
reirei应助xiaowang采纳,获得10
12秒前
魔幻擎宇发布了新的文献求助10
13秒前
13秒前
13秒前
顾矜应助SHD采纳,获得10
14秒前
14秒前
yxy完成签到,获得积分10
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974856
求助须知:如何正确求助?哪些是违规求助? 3519400
关于积分的说明 11198085
捐赠科研通 3255563
什么是DOI,文献DOI怎么找? 1797860
邀请新用户注册赠送积分活动 877208
科研通“疑难数据库(出版商)”最低求助积分说明 806219