氧化应激
绿原酸
细胞凋亡
化学
氧化磷酸化
细胞生物学
生物化学
生物
食品科学
作者
Tian Xu,Jilei Zhang,Qiang Guo,Guangyu Wang,Wei He,Zhiyong Li,Dong Jing-Ming
出处
期刊:Acta Poloniae Pharmaceutica
[Polish Pharmaceutical Society]
日期:2021-01-15
卷期号:77 (6): 881-887
标识
DOI:10.32383/appdr/130824
摘要
Chlorogenic acid (CGA), a type of polyphenolic compound formed by esterification of caffeic and quinic acids, is the major active ingredient found in many traditional Chinese medicines such as Flos Lonicerae Japonicae and Eucommia ulmoides, and it is also abundant in some fruits, dietary vegetables, and daily beverages like coffee, beans, pineapple and apples (1, 2).CGA has been reported a wide range of diverse pharmacological effects, including anti-oxidative, anti-inflammatory, and anti-carcinogenic activities (2-4).As its natural and ubiquitous existence and its pharmacological effects such as anti-oxidative capacity, exploration of the clinical application on some common epidemics means great significance and prospect.Currently, 424 million people aged between 20 and 79 years worldwide are diabetic.The long-term metabolic disorder caused by diabetes leads to damage in multiple organs and systems (5).Meanwhile, long-term hyperglycemia caused by diabetes affects bone metabolism and causes osteoporosis, delayed or nonunion of fracture healing except for the cardiovascular and neurological complications (6).Diabetes-induced osteoporosis (DM-OS) is caused by chronic hyperglycemia, advanced glycated end products, and oxidative stress.The increase in the prevalence of DM-OS has prompted researchers to develop new biological therapies for the management of DM-OS (5).
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