Ursolic acid alleviates heat stress-induced lung injury by regulating endoplasmic reticulum stress signaling in mice

熊果酸 未折叠蛋白反应 超氧化物歧化酶 促炎细胞因子 丙二醛 内质网 肿瘤坏死因子α 药理学 化学 乳酸脱氢酶 切碎 氧化应激 内分泌学 生物化学 内科学 生物 医学 炎症 色谱法
作者
Ying Yang,Changwu Li,Ning Liu,Mengmeng Wang,Xiumin Zhou,In Ho Kim,Zhenlong Wu
出处
期刊:Journal of Nutritional Biochemistry [Elsevier]
卷期号:89: 108557-108557 被引量:24
标识
DOI:10.1016/j.jnutbio.2020.108557
摘要

Acute lung injury has been reported to be associated with heat stress in various animals. Ursolic acid is a natural pentacyclic triterpenoid compound with multiple bioactivities. However, it remains unknown whether ursolic acid supplementation alleviates heat stress-induced lung injury. In the present study, male Institute of Cancer Research mice were left untreated under a normal temperature condition (23±1°C), receiving orally administrated with vehicle (phosphate buffered saline) or ursolic acid (40 mg/kg BW−1·d−1 for 2 d), and then were subjected to high temperature (41±1°C) for 2 h. Histological alterations, activities of antioxidative enzymes, apoptosis, generation of reactive oxygen species, abundance of inflammatory cytokines, and endoplasmic reticulum stress-related proteins were analyzed. Compared with the controls, heat stress treatment led to enhanced apoptosis, increased H2O2 production, and upregulated protein levels of inflammatory cytokines in the serum, including tumor necrosis factor alpha, interleukin-6, and interleukin-1 beta. Activities of malondialdehyde, lactate dehydrogenase, and myeloperoxidase were increased, while the activities for superoxide dismutase and catalase were reduced in lung tissues of mice. All these alterations were significantly prevented by ursolic acid administration. Further study showed that heat stress led to activation of protein kinase-like ER kinase eukaryotic initiation factor 2 alpha -the transcription factor CCAAT-enhancer-binding protein homologous protein (CHOP) signaling, which was attenuated by ursolic acid supplementation. These findings indicated that ursolic acid pretreatment protected lung tissues against heat stress-induced injury by regulating inflammatory cytokines and unfolded protein response in mice. Ursolic acid supplementation might be a therapeutic strategy to alleviate high temperature-induced lung injury in humans and animals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
赘婿应助李一鹏采纳,获得30
刚刚
耿昭发布了新的文献求助10
刚刚
ccccccwq完成签到,获得积分10
刚刚
1秒前
Hygge发布了新的文献求助10
2秒前
赘婿应助xiaolianwheat采纳,获得10
2秒前
岳岳岳发布了新的文献求助10
2秒前
枸橼酸发布了新的文献求助10
3秒前
3秒前
4秒前
车紊完成签到,获得积分10
4秒前
pursue发布了新的文献求助10
4秒前
Inevitable发布了新的文献求助10
4秒前
4秒前
4秒前
mensa发布了新的文献求助10
5秒前
宋佳佳发布了新的文献求助10
5秒前
flyingsoul发布了新的文献求助10
5秒前
小小人儿完成签到,获得积分10
6秒前
6秒前
小飞完成签到,获得积分20
6秒前
淡淡十三完成签到,获得积分10
7秒前
大吉岭发布了新的文献求助10
7秒前
tiantibaba发布了新的文献求助10
7秒前
aa发布了新的文献求助30
7秒前
在水一方应助fy采纳,获得10
7秒前
mermaid完成签到,获得积分10
7秒前
8秒前
8秒前
杨偲艺发布了新的文献求助10
8秒前
星期八完成签到,获得积分10
8秒前
8秒前
星辰大海应助如意元霜采纳,获得10
9秒前
9秒前
10秒前
大梦想家完成签到,获得积分20
10秒前
10秒前
xiaoyu发布了新的文献求助10
10秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546888
求助须知:如何正确求助?哪些是违规求助? 3123917
关于积分的说明 9357332
捐赠科研通 2822504
什么是DOI,文献DOI怎么找? 1551513
邀请新用户注册赠送积分活动 723546
科研通“疑难数据库(出版商)”最低求助积分说明 713791