对抗
变构调节
变构调节剂
化学
药理学
受体
竞争对手
敌手
兴奋剂
功能选择性
G蛋白偶联受体
出处
期刊:Molecular Interventions
[CLOCKSS Archive]
日期:2004-08-01
卷期号:4 (4): 222-229
被引量:66
摘要
Allosteric antagonists modulate the affinity and/or efficacy of agonists for receptors. Although the manner in which this modulation can occur can mimic that of simple competitive antagonists, allosteric antagonists possess unique properties that can present seemingly capricious profiles of antagonism. These unique properties also offer potentially useful patterns for therapeutic utility. This review summarizes methods to detect allosteric antagonism and some special properties of these receptor modulators.
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