Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives.

HomeCirculationVol. 87, No. 3Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessAbstractPDF/EPUBVascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives. V J Dzau, G H Gibbons, J P Cooke and N Omoigui V J DzauV J Dzau Falk Cardiovascular Research Center, Stanford University School of Medicine, Calif. 94305-5246. , G H GibbonsG H Gibbons Falk Cardiovascular Research Center, Stanford University School of Medicine, Calif. 94305-5246. , J P CookeJ P Cooke Falk Cardiovascular Research Center, Stanford University School of Medicine, Calif. 94305-5246. and N OmoiguiN Omoigui Falk Cardiovascular Research Center, Stanford University School of Medicine, Calif. 94305-5246. Originally published1 Mar 1993https://doi.org/10.1161/01.CIR.87.3.705Circulation. 1993;87:705–719 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Zaric B, Obradovic M, Trpkovic A, Banach M, Mikhailidis D and Isenovic E Endothelial Dysfunction in Dyslipidaemia: Molecular Mechanisms and Clinical Implications, Current Medicinal Chemistry, 10.2174/0929867326666190903112146, 27:7, (1021-1040) Zhang Q, Lyu W, Yu M and Niu Y (2020) Sulfur dioxide induces vascular relaxation through PI3K/Akt/eNOS and NO/cGMP signaling pathways in rats, Human & Experimental Toxicology, 10.1177/0960327120911428, 39:8, (1108-1117), Online publication date: 1-Aug-2020. 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In particular, the vascular endothelium has emerged as the central focus of many of the biologic events that affect the preoperative, operative, and postoperative course of nearly all heart surgery patients. A recurring theme in the study of endothelial cell biology is the crucial role that endothelial cell injury plays in the difficulties that our patients encounter. The deleterious effects of endothelial cell injury are most evident in the acute syndromes of vasospasms, coagulopathy, ischemia/reperfusion injury, and the systemic inflammatory response to cardiopulmonary bypass. In addition, chronic endothelial cell injury contributes to the development of anastomotic narrowing and the progression of atherosclerosis, both of which limit the long-term success of coronary artery bypass grafting. 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