青蒿琥酯
蒿甲醚
维维里尼阿匹索氏菌
华支睾吸虫
吡喹酮
药理学
医学
华支睾吸虫病
体内
奥皮斯托奇斯
口服
生物
传统医学
青蒿素
免疫学
血吸虫病
疟疾
肝吸虫
生物技术
蠕虫
恶性疟原虫
作者
Jennifer Keiser,Shu-Hua Xiao,Jian Xue,Chang Zhen-San,Peter Odermatt,Smarn Tesana,Marcel Tanner,Jürg Utzinger
标识
DOI:10.1016/j.ijantimicag.2006.08.004
摘要
Food-borne trematodiasis is an emerging public health problem and there is a need to develop novel treatment options. We examined the in vivo efficacy of single oral doses of artesunate and artemether administered to rodents experimentally infected with either Clonorchis sinensis or Opisthorchis viverrini. Rats infected with adult C. sinensis were administered artesunate or artemether at doses of 75, 150 or 300 mg/kg. Hamsters infected with adult O. viverrini were administered artesunate or artemether at doses of 200, 400 or 600 mg/kg. Treatment efficacy was assessed according to reductions in worm burden compared with infected but untreated control animals. Worm burden reductions of 98.6–100% were found in C. sinensis-infected rats after a single dose of artesunate and artemether at 150 mg/kg. Administration of artesunate and artemether at a dose of 400 mg/kg to O. viverrini-infected hamsters resulted in worm burden reductions of 77.6% and 65.5%, respectively. However, both drugs showed toxic effects when administered to O. viverrini-infected hamsters at a dose ≥400 mg/kg. Our study demonstrates that artesunate and artemether possess excellent clonorchicidal activities in vivo. These findings provide a foundation for subsequent clinical trials. More laboratory investigations are warranted to investigate further the opisthorchicidal properties of the artemisinins.
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