DNA甲基化
表观遗传学
精神分裂症(面向对象编程)
遗传学
生物
候选基因
甲基化
基因
生物信息学
计算生物学
医学
精神科
基因表达
作者
Xiaofen Zong,Maolin Hu,Zongchang Li,Hongbao Cao,Xiaogang Chen,Jinsong Tang
标识
DOI:10.1007/s11434-014-0690-y
摘要
Schizophrenia is a heterogeneous psychiatric disorder broadly accepted being caused by genetic and environmental factors. Although conventional genetic studies have identified some candidate genes for schizophrenia, low odds ratios and penetrance, and a lack of reproducibility have limited their explanatory power. Despite the major efforts made toward identifying environmental factors in schizophrenia, methodological limitations and inconsistent findings of epidemiological reports have obstructed attempts to identify exogenous causal factors. Epigenetic mechanisms, mediating between environment and genes, have recently been proposed to play an important role in the pathogenesis of schizophrenia. DNA methylation is the most stable and well-characterized epigenetic modification. In this paper, we briefly introduce DNA methylation mechanisms, genome-wide DNA methylation studies, and identify specific genomic methylation sites in individuals diagnosed with schizophrenia. The outline candidate genes such as Reelin and COMT, are also outlined before paying attention to the conundrum of recent researches.
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