2尼泊尔卢比
NPR1
利钠肽
环磷酸鸟苷
心钠素
内科学
内分泌学
受体
脑利钠肽
肽类激素
古西亚德
化学
生物
鸟苷酸环化酶2C
环化酶
医学
心力衰竭
一氧化氮
作者
Kerry J. Koller,David Lowe,Gregory L. Bennett,Naoto Minamino,Kenji Kangawa,Hisayuki Matsuo,David V. Goeddel
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1991-04-05
卷期号:252 (5002): 120-123
被引量:698
标识
DOI:10.1126/science.1672777
摘要
The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3′,5′-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.
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