聚合物
氢氧化物
材料科学
化学工程
层状双氢氧化物
共聚物
控制释放
胰岛素
高分子化学
高分子科学
纳米技术
复合材料
医学
工程类
内分泌学
作者
Mehrdad Mahkam,Mina Davatgar,Zolfaghar Rezvani,Kamellia Nejati
标识
DOI:10.1080/00914037.2011.617337
摘要
The present work introduces new hybrid material based on the combination of layered double hydroxides (LDH) and a pH-sensitive polymer (PSP), alginate, a polysaccharide widely applied for encapsulating drugs to produce a LDH–polymer nanocomposite, able to act as an effective drug delivery system (DDS) in comparison to the Zn–Al LDH or the polymer alone. Insulin has been chosen as a model drug, being loaded in a Zn–Al LDH matrix. In vitro release profiles were established separately in both the presence and absence of glucose phosphate in pH 7. Drug release studies showed that the in the presence of glucose phosphate release rate increases.
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