大黄素
吴茱萸碱
沃戈宁
黄芩素
黄芩
细胞凋亡
蒽醌类
中医药
传统医学
白杨素
小檗碱
雷公藤甲素
黄酮类
癌症
药理学
吴茱萸碱
天然产物
植物化学
医学
化学
生物
生物化学
类黄酮
抗氧化剂
替代医学
病理
内科学
植物
色谱法
出处
期刊:Cancer Letters
[Elsevier]
日期:2010-08-04
卷期号:332 (2): 304-312
被引量:294
标识
DOI:10.1016/j.canlet.2010.07.015
摘要
The traditional Chinese medicine (TCM) uses a combination of different natural products based on practical experiences. To better understand the therapeutic functions of TCM, large efforts have been made to identify the principle constituents of TCM and to unravel the molecular mechanisms behind the efficacy observed. This review aims to summarize research results obtained from the most intensively studied TCM phytochemical compounds namely the alkaloids Berberine, Evodiamine; anthraquinones Emodin, Aloe-emodin, Rhein; the terpenoids Artemisinin, Celastrol, Triptolide; the flavones Apigenin, Chrysin, Wogonin, Baicalein; and the cyclopenta[b]benzofuran derivatives Rocaglamide. Most of them have been originally identified as anti-inflammatory and anti-viral reagents and are now known to also possess anti-tumor activities by targeting the apoptosis pathways in cancer. This review also intends to give an overview of the mechanisms of action identified so far. These breakthrough findings may have important implications for targeted-cancer therapy and for modernization of TCM.
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