炎症体
纳米载体
先天免疫系统
Toll样受体
阳离子聚合
伤亡人数
受体
信号转导
化学
细胞生物学
生物
药物输送
免疫学
生物化学
有机化学
作者
Caroline Lonez,Michel Bessodes,Daniel Scherman,Michel Vandenbranden,Virginie Escriou,Jean Marie Ruysschaert
标识
DOI:10.1016/j.nano.2013.12.003
摘要
We provide evidence that cationic lipids, usually considered as a safe alternative to viral vectors as nanocarriers for gene therapy or drug intracellular delivery, do not behave as inert material but do activate cellular signalling pathways implicated in inflammatory reactions. We show here that the cationic lipid RPR206252 induces NF-κB activation, and the production of TNF-α, IL-1β, IL-6 and IFN-γ by human or mouse macrophage cell lines. Further, we demonstrate that the activation of inflammatory cascades by RPR206252 is dependent on Toll-like receptor 2 (TLR2), the natural sensor of bacterial lipopeptides and NOD-like receptor protein 3 (NLRP3), the major inflammasome component. Our results suggest that cationic lipid nanocarriers because of their ability to stimulate the innate system can be used as a new class of synthetic and safe adjuvant for vaccination.Cationic lipid nanocarriers are typically considered neutral tools for gene delivery. However, as demonstrated in this study, they possess a clear ability to stimulate the innate immune system, and actually can be used as a new class of synthetic and safe adjuvant for vaccination.
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