生物
癌症干细胞
癌症
干细胞
癌细胞
遗传模型
计算生物学
癌症的体细胞进化
进化生物学
遗传学
生物信息学
基因
作者
Antonija Kreso,John E. Dick
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2014-03-01
卷期号:14 (3): 275-291
被引量:1781
标识
DOI:10.1016/j.stem.2014.02.006
摘要
Genetic analyses have shaped much of our understanding of cancer. However, it is becoming increasingly clear that cancer cells display features of normal tissue organization, where cancer stem cells (CSCs) can drive tumor growth. Although often considered as mutually exclusive models to describe tumor heterogeneity, we propose that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity. We offer an approach to integrating CSCs and cancer genetic data that will guide the field in interpreting past observations and designing future studies.
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