Dendocarbins A−N, New Drimane Sesquiterpenes from the Nudibranch Dendrodoris carbunculosa

Fourteen new sesquiterpenes of the drimane series dendocarbins A−N (1−14) were obtained from ethanol extracts of the Japanese nudibranch Dendrodoris carbunculosa, together with two known compounds, isodrimeninol (15) and 11-epivaldiviolide (16). All structures were elucidated mainly from spectral data, and most of these sesquiterpenes were found to exhibit cytotoxicity. In addition, isodrimeninol (15), the major sesquiterpene of this animal, was found to have a sharp peppery taste.