钙调神经磷酸酶
移植
西罗莫司
医学
PI3K/AKT/mTOR通路
癌症研究
癌症
肿瘤进展
免疫学
药理学
生物
信号转导
内科学
生物化学
作者
Aninda Basu,Tao Liu,Pallavi Banerjee,Evelyn Flynn,David Zurakowski,Dipak Datta,Ondřej Viklický,Martin Gasser,Ana Maria Waaga-Gasser,Jun Yang,Soumitro Pal
出处
期刊:Cancer Letters
[Elsevier]
日期:2012-08-01
卷期号:321 (2): 179-186
被引量:13
标识
DOI:10.1016/j.canlet.2012.02.004
摘要
Calcineurin inhibitors (CNIs) may promote post-transplantation cancer through altered expression of cytokines and chemokines in tumor cells. We found that there is a potential cross-talk among CNI-induced signaling molecules and mTOR. Here, we utilized a murine model of post-transplantation cancer to examine the effect of a combination therapy (CNI + mTOR-inhibitor rapamycin) on allograft survival and renal cancer progression. The therapy prolonged allograft survival; and significantly attenuated CNI-induced post-transplantation cancer progression, with down-regulation of mTOR and S6-kinase phosphorylation. Also, rapamycin inhibited CNI-induced over-expression of the angiogenic cytokine VEGF, and the chemokine receptor CXCR3 and its ligands in post-transplantation tumor tissues.
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