SOX2
生物
重编程
诱导多能干细胞
KLF4公司
胚芽层
外周血单个核细胞
细胞生物学
分子生物学
免疫学
转录因子
胚胎干细胞
遗传学
细胞
基因
体外
作者
Tao Wang,Wenjing Tang,Quan Zeng,Shuai Miao,Chenghui Pi,Yingji Li,Wen Yue,Shengyuan Yu
标识
DOI:10.1016/j.scr.2022.102735
摘要
Peripheral blood mononuclear cells (PBMC) were donated by a healthy 25-year-old Han Chinese man and reprogrammed with human transcription factors (Oct4, Sox2, Klf4, and c-Myc) using CytoTune™-iPS 2.0 Sendai Reprogramming Kit. The pluripotency was confirmed by pluripotency markers. The iPSC lines could be differentiated into three germ layers and be used as a control in drug development and studies on pathological mechanisms.
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