Next-generation sequencing reveals tumour origin in a patient with rare metachronous colonic metastasis from pancreatic cancer

Cancer of unknown primary site accounts for less than 5% of all malignant neoplasms, identifying the correct primary site of malignancy is essential for staging and following treatments [ [1] Welch D.R. Hurst D.R. Defining the hallmarks of metastasis. Cancer Res. 2019; 79: 3011-3027https://doi.org/10.1158/0008-5472.CAN-19-0458 Crossref PubMed Scopus (192) Google Scholar ]. To date, there is no data on molecular profiling using next-generation sequencing (NGS) in accurately determining metachronous colonic metastasis from pancreatic cancer.