Human Biomonitoring (HBM)-I values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) - Description, derivation and discussion

全氟辛酸 全氟辛烷 生物监测 化学 环境化学 激素 生理学 生物 生物化学 有机化学 磺酸盐
作者
Jürgen Hölzer,Hellmuth Lilienthal,M. Schümann
出处
期刊:Regulatory Toxicology and Pharmacology [Elsevier BV]
卷期号:121: 104862-104862 被引量:29
标识
DOI:10.1016/j.yrtph.2021.104862
摘要

In 2016, the German Human Biomonitoring Commission (HBM-C) published a statement on its decision to develop HBM-I values for Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS) (Bundesgesundheitsbl 2016, 59:1364 DOI 10.1007/s00103-016-2437-1). The HBM-I value corresponds to the concentration of a substance in a human biological material below which no adverse health effects are expected, according to current knowledge and assessment by the HBM-C, and, consequently, there is no need for action. Evidence for associations between PFOA- and PFOS-body burden and health outcomes was found for fertility and pregnancy, weights of newborns at birth, lipid metabolism, immunity, sex hormones and age at puberty/menarche, thyroid hormones, onset of menopause as well as uric acid metabolism. Significant contrasts were reported for human blood plasma concentrations between 1 and 10 ng PFOA/mL, and 1–15 ng PFOS/mL, respectively. Within the reported ranges, the HBM-C has decided to set the HBM-I-values at 2 ng PFOA/mL and 5 ng PFOS/mL blood plasma. The underlying pathomechanisms do not appear to be sufficiently clarified to provide an unambiguous explanation of the effects observed. Consistency of toxicological and epidemiological data has been considered. The available data do not indicate an unequivocal proof of a genotoxicity of PFOA and PFOS. • Human biomonitoring (HBM) values are derived by the German HBM-Commission. • HBM-I-value: blood-concentration below which no adverse health effects are expected. • HBM-I is based on epidemiological studies and is supported by animal experiments. • HBM-I-values were set at 2 ng PFOA/mL and 5 ng PFOS/mL blood plasma (or serum).
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