T Cell Therapies for Cancer

The introduction and development of T cell-based therapies to treat a variety of both hematological and solid tumors have led to substantial clinical benefits in some patients. In this brief review we introduce the different T cell modalities used and some of their key features and limitations. Emerging avenues to overcome current bottlenecks are put into perspective, especially the issues of limited persistence and efficacy that make it challenging to achieve durable clinical responses in solid tumor indications.