坏死性下垂
移植
体内
细胞凋亡
缺血
医学
体外
活性氧
药理学
程序性细胞死亡
癌症研究
细胞生物学
生物
外科
内科学
生物化学
生物技术
作者
Rui Hou,Tianxiang Lu,Wei Gao,Jian Shen,Zheyuan Yu,Datao Li,Ruhong Zhang,Yuanyi Zheng,Xiaojun Cai
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-05-13
卷期号:16 (6): 9559-9571
被引量:38
标识
DOI:10.1021/acsnano.2c02832
摘要
Ischemia–reperfusion (I/R) injury leads to a low success rate of skin flap transplantation in reconstruction surgery, thus requiring development of new treatments. Necroptosis and apoptosis pathways, along with overexpression of reactive oxygen species and pro-inflammatory factors in skin flap transplantation, are deemed as potential therapeutic targets. This study provides a paradigm for nanozyme-mediated microenvironment maintenance to improve the survival rate of the transplanted skin flap. Prussian blue nanozyme (PBzyme) with multiple intrinsic biological activities was constructed and selected for this proof-of-concept study. The prepared PBzyme shows anti-inflammatory, antiapoptotic, antinecroptotic, and antioxidant activities in both in vitro and in vivo models of I/R injured skin flaps. The multiple inhibitory effects of PBzyme maintained a normal microenvironment and thus significantly promoted the survival rate of the I/R injured skin flap (from 37.21 ± 8.205% to 79.61 ± 7.5%). Of note, PBzyme regulated the expression of the characteristic signal molecules of necroptosis, including Rip 1, Rip 3, and pMLKL, indicating that PBzyme may be a therapeutic agent for necroptosis-related diseases. This study shows great prospects for clinical application of PBzyme in the treatment of skin flaps via local administration.
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