Different Metabolic Phenotypes of Obesity and Risk of Coronary Artery Calcium Progression and Incident Cardiovascular Disease Events: The CARDIA Study.

医学 危险系数 肥胖 代谢综合征 内科学 体质指数 冠状动脉疾病 疾病 冠状动脉钙 心脏病学
作者
Jing-Wei Gao,Si You,Zhao-Yu Liu,Qing-Yun Hao,Jing-Feng Wang,Dominique A Vuitton,Shao-Ling Zhang,Pin-Ming Liu
出处
期刊:Arteriosclerosis, Thrombosis, and Vascular Biology [Lippincott Williams & Wilkins]
卷期号:42 (5): 677-688
标识
DOI:10.1161/atvbaha.122.317526
摘要

To investigate whether obesity with or without metabolic syndrome is prospectively associated with coronary artery calcium (CAC) progression and incident cardiovascular disease events.A total of 1730 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults) were included (age, 40.1±3.6 years; 38.3% men), who completed computed tomography of CAC at baseline (year 15: 2000-2001) and follow-up (year 20 or 25). Metabolically healthy obesity (MHO) was defined as body mass index≥30 kg/m2 without any metabolic syndrome components in our main analysis. Sensitivity analyses were conducted for several conditions characterizing 4 metabolic phenotypes.During a mean follow-up of 9.1 years, 439 participants had CAC progression. MHO subjects had a significantly higher risk of CAC progression than their metabolically healthy normal weight counterparts (adjusted hazard ratios [95% CIs] from 1.761 [1.369-2.264] to 2.047 [1.380-3.036]) depending on the definition of MHO adopted. Obesity with unhealthy metabolic profile remained the highest significant risk of CAC progression and cardiovascular disease events whatever the definitions adopted for metabolically unhealthy status. Up to 60% of participants with MHO converted to metabolically unhealthy obesity from year 15 to year 20 or year 25. Further sensitivity analysis showed that MHO throughout carried a similar risk of incident cardiovascular disease events compared with metabolically healthy normal weight throughout.Different metabolic phenotypes of obesity beginning at a young age exhibit distinct risks of CAC progression and subsequent cardiovascular disease events in later midlife. MHO represents an intermediate phenotype between metabolically low- to high-risk obese individuals.URL: https://www.gov; Unique identifier: NCT00005130.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
天天快乐应助自己采纳,获得10
1秒前
hzw完成签到,获得积分20
4秒前
科研狗完成签到 ,获得积分10
6秒前
hzw发布了新的文献求助30
7秒前
友好寻真发布了新的文献求助10
8秒前
8秒前
11秒前
12秒前
12秒前
月如钩发布了新的文献求助10
12秒前
念初完成签到 ,获得积分10
15秒前
澡雪发布了新的文献求助10
16秒前
16秒前
魏为维发布了新的文献求助10
17秒前
搜集达人应助欣欣子采纳,获得10
18秒前
追寻书雁完成签到 ,获得积分10
19秒前
22秒前
tianmeiling完成签到 ,获得积分10
23秒前
天天快乐应助魏为维采纳,获得10
24秒前
LAVINE完成签到 ,获得积分10
24秒前
搜集达人应助儒雅致远采纳,获得30
24秒前
25秒前
26秒前
27秒前
影子发布了新的文献求助10
28秒前
可爱思山发布了新的文献求助40
28秒前
30秒前
白露完成签到 ,获得积分10
31秒前
香蕉觅云应助初之采纳,获得10
32秒前
liars发布了新的文献求助10
32秒前
量子星尘发布了新的文献求助10
33秒前
fei完成签到,获得积分10
34秒前
共享精神应助孙成成采纳,获得10
34秒前
34秒前
kjz发布了新的文献求助30
35秒前
不要讨好十三完成签到,获得积分10
36秒前
37秒前
阿达完成签到,获得积分20
37秒前
科研通AI2S应助科研通管家采纳,获得10
37秒前
搜集达人应助科研通管家采纳,获得10
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975543
求助须知:如何正确求助?哪些是违规求助? 3519971
关于积分的说明 11200248
捐赠科研通 3256311
什么是DOI,文献DOI怎么找? 1798213
邀请新用户注册赠送积分活动 877446
科研通“疑难数据库(出版商)”最低求助积分说明 806338