脱发
毛囊
头发周期
微泡
毛乳头
细胞生物学
再生(生物学)
间充质干细胞
斑秃
外体
米诺地尔
干细胞
毛发生长
生物
胚胎干细胞
Wnt信号通路
内分泌学
内科学
化学
免疫学
医学
生理学
生物化学
信号转导
小RNA
遗传学
基因
作者
Hyo‐Suk Kim,Yeongji Jang,Eun Hye Kim,Hochung Jang,Haeun Cho,Geonhee Han,Hyun Kyu Song,Sun Hwa Kim,Yoosoo Yang
标识
DOI:10.3389/fcell.2022.815205
摘要
Human hair dermal papillary (DP) cells comprising mesenchymal stem cells in hair follicles contribute critically to hair growth and cycle regulation. The transition of hair follicles from telogen to anagen phase is the key to regulating hair growth, which relies heavily on the activation of DP cells. In this paper, we suggested exosomes derived from bovine colostrum (milk exosomes, Milk-exo) as a new effective non-surgical therapy for hair loss. Results showed that Milk-exo promoted the proliferation of hair DP cells and rescued dihydrotestosterone (DHT, androgen hormones)-induced arrest of follicle development. Milk-exo also induced dorsal hair re-growth in mice at the level comparable to minoxidil treatment, without associated adverse effects such as skin rashes. Our data demonstrated that Milk-exo accelerated the hair cycle transition from telogen to anagen phase by activating the Wnt/β-catenin pathway. Interestingly, Milk-exo has been found to stably retain its original properties and efficacy for hair regeneration after freeze-drying and resuspension, which is considered critical to use it as a raw material applied in different types of alopecia medicines and treatments. Overall, this study highlights a great potential of an exosome from colostrum as a therapeutic modality for hair loss.
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