信号
T细胞受体
效应器
生物
细胞生物学
信号转导
剧目
T细胞
细胞内
免疫系统
免疫学
声学
物理
作者
Guillaume Gaud,Renaud Lesourne,Paul E. Love
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2018-05-22
卷期号:18 (8): 485-497
被引量:411
标识
DOI:10.1038/s41577-018-0020-8
摘要
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major question for investigation. Recent years have witnessed important advances in our understanding of the regulatory processes that control and modulate the TCR signalling response. Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical cellular processes - namely, positive selection and T cell homeostasis.
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