重性抑郁障碍
单胺类
神经炎症
谷氨酸的
机制(生物学)
神经科学
心理学
疾病
炎症
医学
免疫学
内科学
谷氨酸受体
认知
受体
认识论
哲学
血清素
作者
Marie Woelfer,Vanessa Kasties,Sascha Kahlfuß,Martín Walter
出处
期刊:Neuroscience
[Elsevier]
日期:2019-04-01
卷期号:403: 93-110
被引量:105
标识
DOI:10.1016/j.neuroscience.2018.03.034
摘要
Major depressive disorder (MDD) is a very common disease that affects more than 350 million people worldwide, representing an enormous socioeconomic burden. From a clinical perspective, MDD can be divided into different subtypes, such as melancholic or atypical MDD. Interestingly, increasing evidence points toward an involvement of the immune system in MDD pathogenesis. However, inflammation does not seem to have the same impact on every MDD type. Here, we describe how inflammation can affect monoaminergic and glutamatergic neurotransmission, which provides a possible mechanism for MDD onset. Next, we examine the regional specificity of neuroinflammation, which shows striking overlaps with neural patterns activated in atypical MDD. Furthermore, we outline how inflammation may translate to subtype-specific clinical features and we suggest how this could be used for diagnostic and treatment purposes. By providing a link back to a dysregulated immune system as a contributing factor to MDD subtypes, we explain how brain regions particularly affected by certain subtypes may regulate the cortisol circuitry.
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