PRDX-1 supports the survival and antitumor activity of primary and CAR-modified NK cells under oxidative stress

NK cells are susceptible to oxidative stress in the TME. Priming with IL15 upregulates the antioxidant enzyme PRDX1 and protects from oxidative stress. PD-L1–CAR NK cells overexpressing PRDX1 exhibit resistance to oxidative stress and improved antitumor function.