微型反应器
试剂
连续流动
流动化学
工艺工程
有机合成
计算机科学
化学
纳米技术
组合化学
衍生化
生化工程
催化作用
材料科学
有机化学
工程类
高效液相色谱法
作者
Shruti Goel,Mihir Khulbe,Anshul Aggarwal,Abha Kathuria
出处
期刊:Molecular Diversity
[Springer Science+Business Media]
日期:2021-10-18
卷期号:26 (5): 2939-2948
被引量:2
标识
DOI:10.1007/s11030-021-10338-9
摘要
In the current scenario, flow chemistry is emerging as a significant in the field of organic synthesis. This miniaturized protocol including microreactors facilitates excellent heat transfer, low solvent wastage, lesser reaction time, a safer environment for reagent handling and appreciable yields of desired products. Thus, this enabling technology has a great scope in the synthesis and preparation of a variety of heterocycles that require toxic reagents as starting materials. This review discusses the recent advances (2020-2021) in continuous flow strategy for synthesis and derivatization of variety of heterocyclic entities, of different ring size, using different approaches. This also highlights the advantages of different combined techniques like Microwave assisted heating, electrochemical flow cell, LED light source, NMR and FT-IR analysis, etc., that enables utilization of various mechanisms and real-time monitoring of reactions leading to improved results.
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