暴露的
生物监测
危险废物
环境科学
污水
人口
暴露评估
环境卫生
毒理
废物管理
环境化学
生物
环境工程
生态学
化学
医学
工程类
作者
Ruben Gil-Solsona,Maria-Christina Nika,Mariona Bustamante,Cristina M. Villanueva,Maria Foraster,Marta Cosín-Tomás,Nikiforos A. Alygizakis,María Dolores Gómez-Roig,Elisa Llurba-Olive,Jordi Sunyer,Nikolaos S. Thomaidis,Payam Dadvand,Pablo Gago-Ferrero
出处
期刊:Environmental Science and Technology Letters
[American Chemical Society]
日期:2021-11-12
卷期号:8 (12): 1077-1084
被引量:7
标识
DOI:10.1021/acs.estlett.1c00848
摘要
Chemicals are part of our daily lives, and we are exposed to numerous chemicals through multiple pathways. Relevant scientific evidence contributing to the regulation of hazardous chemicals require a holistic approach to assess simultaneous exposure to multiple compounds. Biomonitoring provides an accurate estimation of exposure to chemicals through very complex and costly sampling campaigns. Finding efficient proxies to predict the risk of chemical exposure in humans is an urgent need to cover large areas and populations at a reasonable cost. We conducted an exploratory study to characterize the human chemical exposome in maternal blood and placenta samples of a population-based birth cohort in Barcelona (2018-2021). Ultimate HRMS-based approaches were applied including wide-scope target, suspect, and nontarget screening. Forty-two chemicals were identified including pesticides, personal care products, or industrial compounds, among others, in the range of ng/mL and ng/g. In parallel, sewage sludge from the wastewater treatment plants serving the residence areas of the studied population were also screened, showing correlations with the type and concentrations of chemicals found in humans. Our findings were suggestive for the potential use of sewage sludge as a proxy of the human exposure and its application in early warning systems to prevent bioaccumulation of hazardous chemicals.
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