表观遗传学
次生代谢
DNA甲基化
组蛋白
基因表达调控
生物
基因
基因表达
计算生物学
转录因子
细胞生物学
遗传学
生物合成
作者
Yan Zhao,Guanze Liu,Yu Feng,Yanli Li,Qingqing Gao,Chunfan Xiang,Chunquan Li,Runjun Yang,Guanghui Zhang,Huifeng Jiang,Lei Yu,Shengchao Yang
标识
DOI:10.1186/s43897-023-00059-y
摘要
Medicinal plants represent a huge reservoir of secondary metabolites (SMs), substances with significant pharmaceutical and industrial potential. However, obtaining secondary metabolites remains a challenge due to their low-yield accumulation in medicinal plants; moreover, these secondary metabolites are produced through tightly coordinated pathways involving many spatiotemporally and environmentally regulated steps. The first regulatory layer involves a complex network of transcription factors; a second, more recently discovered layer of complexity in the regulation of SMs is epigenetic modification, such as DNA methylation, histone modification and small RNA-based mechanisms, which can jointly or separately influence secondary metabolites by regulating gene expression. Here, we summarize the findings in the fields of genetic and epigenetic regulation with a special emphasis on SMs in medicinal plants, providing a new perspective on the multiple layers of regulation of gene expression.
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