芳香烃受体
先天性淋巴细胞
免疫系统
先天免疫系统
转录因子
免疫学
生物
获得性免疫系统
发病机制
自身免疫
受体
细胞生物学
基因
遗传学
作者
Wei Huang,Ke Rui,X Wang,Na Peng,Wenhao Zhou,Xiaofei Shi,Liwei Lu,Dajun Hu,Jie Tian
标识
DOI:10.1016/j.jaut.2023.103049
摘要
As a ligand-activated transcription factor, the aryl hydrocarbon receptor (AhR) is activated by structurally diverse ligands derived from the environment, diet, microorganisms, and metabolic activity. Recent studies have demonstrated that AhR plays a key role in modulating both innate and adaptive immune responses. Moreover, AhR regulates innate immune and lymphoid cell differentiation and function, which is involved in autoimmune pathogenesis. In this review, we discuss recent advances in understanding the mechanism of activation of AhR and its mediated functional regulation in various innate immune and lymphoid cell populations, as well as the immune-regulatory effect of AhR in the development of autoimmune diseases. In addition, we highlight the identification of AhR agonists and antagonists that may serve as potential therapeutic targets for the treatment of autoimmune disorders.
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